Human immunodeficiency virus (HIV) has become one of the most extensively studied and notorious pathogen in history, becoming one of the major public health challenges of modern times. Nevertheless, since the introduction of combined antiretroviral therapy (cART) the life expectancy of HIV-positive patients has increased to such magnitude that nowadays HIV infection is thought-out as a chronic controllable disease leading to an unforeseen growth in chronic non-acquired immune deficiency syndrome (AIDS) comorbidities, similar to those experienced in the elderly, and to a decrease in immunodeficiency-associated episodes. The resemblance between ageing and the course of HIV infection, imply that HIV infection may compress the ageing process, accelerating some comorbidities [1–4]. The majority of these age-associated diseases are the result of the persistent inflammation and activation of the immune system [5], which is described as “inflammageing” [6, 7], or in the event of AIDS, “inflammaids”, considering the alterations that appear during HIV infection (which are similar to those which occur during immunosenescence) [8].


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